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NIH Pharmacogenetics Research Network (PGRN)
Description
The NIH Pharmacogenetics Research Network (PGRN), led by the National Institute of
General Medical Sciences, was formed in 2000 to enable a network of multi-disciplinary
research groups to conduct studies addressing research questions in pharmacogenetics and
pharmacogenomics and to populate a knowledge base (PharmGKB). The latter will be used as a
research tool to enable future pharmacogenetics studies and should serve as the premier
knowledge base in the field. The PGRN is comprised of 12 independently-funded interactive
research groups, including the knowledge base group and each research group has a focus in
an identified area of pharmacogenetics. The long term goal of the PGRN is to advance
knowledge of the genetic basis for variable drug responses and identify safe and effective
drug therapies designed for individual patients. The PGRN is accomplishing its mission by
conducting studies of variation in human genes relevant to pharmacokinetics (drug
disposition) and pharmacodynamics (drug action), and the relationship of such variation to
drug response phenotypes.
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